Hayden Panettiere is ready to scream for her life once again. The “Heroes” star is reprising her role as Kirby Reed in the upcoming “Scream 6.”

The sixth film of the famed horror franchise marks a big comeback for the 32-year-old amid her various legal and relationship troubles. 

The newest feature will mark the actress’s first big-screen role since she ended a six-season run on the musical series “Nashville” in 2018.

Panettiere starred as the teenager-turned-final-girl in 2011’s “Scream 4.” The fifth “Scream” film was released in January 2022

The next is set to begin principal photography later this summer. Melissa Barrera, Jasmin Savoy Brown, Mason Gooding and Jenna Ortega are also returning for the sixth installment.

The foursome famously survived Ghostface’s killings in the last movie. OG cast members Neve Campbell and Courteney Cox will also be coming back to battle Ghostface.

Co-star David Arquette was killed by the masked killer in the fifth movie. Scream 6 will follow the four survivors as they leave their small town of Woodsboro behind and start a fresh chapter.

Panettiere has mainly stayed out of the spotlight in the last few years amid her ongoing issues with boyfriend Brian Hickerson, whom she started dating in 2018.